From Cape Town International Airport to 59 De Beers Road in Strand, Western Cape, you'll likely want to take the N2 highway towards Somerset West. Here's a rough guide:

1. From the airport, head southwest on Airport Approach Road toward Settlers Way/N2.
2. Merge onto Settlers Way/N2 via the ramp to Somerset.
3. Continue on the N2 for approximately 20-25 kilometers, passing Somerset West.
4. Take exit 43 for Broadway Boulevard/R44 toward Stellenbosch/Somerset West.
5. Keep right at the fork, following signs for R44/Stellenbosch/Somerset West.
6. Merge onto Broadway Boulevard/R44 and continue for several kilometers.
7. Turn left onto Main Road/R44.
8. Continue on Main Road until you reach De Beers Road in Strand.
9. Turn right onto De Beers Road and continue until you reach number 59.

Please note that traffic conditions and road closures can impact travel times and routes, so it's always a good idea to have GPS or a maps app handy for real-time guidance.